R&D and Tailored Pilot Plants

Multi purpose pilot plants for supercritical fluid applications

SEPAREX designs and builds R&D Multi-purpose LAB SYSTEMS and PILOT PLANTS to your specifications. Turn-key and tailored-designed systems designed for process development on a wide range of supercritical fluid and high pressure processes: Extraction and fractionation, reactions, particle formation and formulation, aerogel, drying impregnation or any process that you wish to explore.

Autoclaves and reactors can typically range from 1 to 100 litres. Products and solvents are introduced in the process using SEPAREX high pressure pumping systems: Piston, syringe or membrane pumps, gas compressors. Products are collected at reactor exit through high performance separators, filtration system or any other system specifically developed for your application and environment.

SEPAREX masters most of the high pressure processes

We have developed high-pressure vessel instruments and accessories optimised for the different processes. 

All high-pressure vessels can be either standard and low cost reactors or can be designed specifically for your environment and be ergonomically optimized, adapted to fit your safety requests or your specific product dimensions. 

With SEPAREX, any client has the real choice to define what he needs and to choose exactly the type of system that will fit the application in his given environment. 

We will define and adapt your system to : 

• Your product requirements (toxic products, food products, ultra clean environment, etc…).
• Your installation requirements (lab, clean room, industrial environment, difficult access, etc...).
• Your processe parameters and verstility: Extraction / Fractionation / Reaction / Impregnation / Drying / Cleaning / Crystallisation.
• Vessel detailed characteristics: Size, dimensions, number of vessel, design pressure, design temperature, opening system, instrumentation, etc…
• The solvents and products you want to use (CO₂, fluorinated solvents, hydrogen or flammable fluids, viscous product, fine particle handling system, etc…).
• Product separation (filtration, depressurisation + precipitation, distillation, scrubbing, etc…).
• Quality standard (GMP, specific quality requirement of your company, etc...).
• Design standard (CE, ASME, ATEX, etc…).
• CE marking for pressure components and for the assembly.

Particle collection basket	Scrubber
Cyclonic separator	Fractionation column

SEPAREX will take into account any preferred technical choice you may have, such as:

• Heating by water, oil or electrical heating.
• Preferred suppliers for some components or for some automation system.

SEPAREX will build your plant according to your process and your specification.

SEPAREX will also help you at each step of the project life

• Clear definition of the technical specifications and equipment performances.
• Design validation and interaction with costumer during design.
• Safety analysis of the full system in the operating environment.
• Organisation / Quality system during construction.
• Detailed Factory Acceptance Tests and SAT.
• Training for start-up on operation and maintenance, technical assistance.  
• Optimized operation – advice on operation and scaling-up service after start-up.
• Complete documentation.
• Maintenance: Preventive maintenance service – On-line maintenance service.

Reaction and supercritical water oxidation pilot plants

Applications

• Hydrogenation,
• Oxidation Co₂ acting as solvent, oxidation modulator, pH modulator,
• Many other organic reactions,
• Toxic wastes degradation without emission to atmosphere,
• Hydrolysis and nanoparticle particle formation.

Innovation and challenges

• Energy recovery and operating cost reduction,
• Sludges and viscous solutions pumping,
• Corrosion and salt deposition issues,
• Nanoparticle or toxic material processing: handling and safety issues with collection devices and containment solutions.

???? reactors

For oxidation, hydrogenation or many other reactions, Separex is proposing system working at very high temperature (up to 700°C) and at various pressures and up 1,000 bar.
SEPAREX has developed and built many tailored-made reactors of all size. Equipped with lots of different possible instrumentation for parameter measurement and analysis, mixer, view windows, sampling equipment, and built with the best adapted materials or coating to preserve your equipment and products, you will be able to work all the time in safe, controlled and optimized conditions.

Formulation and Particle formation pilot plants for pharmaceutical applications 

SEPAREX has designed and built many pilot plant and production systems compliant with the pharmaceutical industry requirements.

SEPAREX pharma-equipment are especially designed for taking into account:

• Compliance with cGMP requirements and FDA guidelines in term of traceability, quality system, etc...
• Cleaning requirements of the systems and operation in clean room environment,
• Handling hazardous products in high pressure systems.

SEPAREX has developed many solutions for handling API in a clean and closed environment, cleanable HP components and systems, and solution for operating systems in a safe an performant way.

We develop innovative solutions for your processes and we are able to propose dedicated units designed for your API manufacturing or drug delivery process.